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Glutathione, Allergies and Antioxidant Protection in Lungs

Copyright © 2003 Priya Shah
Reproduction prohibited

The risk of developing respiratory allergies from exposure to diesel emissions depends largely on genetics, according to a study funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).

Researchers from the Keck School of Medicine of the University of Southern California and the David Geffen School of Medicine at UCLA have found that genetic characteristics seen in about half the population leave allergy-sufferers particularly susceptible to the effects of diesel particles.

Here are the relevant findings from the study:

► People with a certain genetic makeup are more susceptible to allergies caused by diesel engine exhaust.

► Antioxidants can detoxify these particles and temper the body's allergic inflammatory response. The better the body can use antioxidants to defend itself, the better it may protect itself from airborne pollutants.

► The enzymes glutathione S-transferase M1, or GSTM1, and glutathione S-transferase P1, or GSTP1 - that metabolize reactive oxygen species and detoxify chemicals present in diesel exhaust - were studied for their role in protecting the lungs.

► GSTM1 occurs in two common forms in the population-either "present" or "null." People born with two of the null form of the gene cannot produce the GSTM1 protective enzyme at all.

► The GSTP1 gene can occur with a common variation called ile105. People born with two of the ile105 form of the gene produce a less-effective form of the GSTP1 enzyme.

► People who lack the GSTM1 enzyme exhibit a larger allergic response than others. Also, those who lack GSTM1 and have at least one GSTP1 ile105 genetic variant show an even larger allergic response to diesel exhaust particles.

► The findings suggest that people who lack the genes to make key antioxidants may have difficulty fighting the harmful effects of air pollution.

► Up to 50 percent of the United States population could be in jeopardy of experiencing health problems related to air pollution because of these genetic variations.

► Overcoming this genetic deficiency could possibly be accomplished by either giving people drugs that replace the role of the genes or by boosting the body's natural defenses.

► Antioxidants may prevent the effects that air pollution have on allergic inflammation.

The study and many others listed here show how glutathione (GSH) is one of the most important antioxidants in the lungs.

The research suggest that boosting levels of antioxidants like glutathione, may prevent the effects that air pollution have on allergic inflammation.

The best way to increase and maintain one's glutathione (GSH) levels is to include animal foods in your diet, as these contain the amino acids needed by the body to synthesize GSH.

An excellent food supplement is un-denatured (non-heated) whey protein that can optimize intracellular glutathione levels.


The Original Article from the Lancet:
Effect of glutathione-S- transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study
F Gilliland et al. [The Lancet; 363 (9403): 119-25 (2004)]

News Reports quoting the study:

Genetic and Environmental Factors Trigger Allergy
Fri 9, January, 2004

Air pollution may significantly worsen respiratory allergies in individuals with genetic risk

Scientists identify genes that regulate allergic response to diesel fumes


More research publications on glutathione

Allergy Remedies:

How I Naturally Cured My Allergy Condition For Life - All natural cure for stopping your allergies in 5 days. Get rid of the following types of allergies, no matter how long you have had them: hay fever, dust mites, pollens and molds, sinusitis, hives, insect bites, and stings. Compared to the cost of doctor visits, over-the-counter remedies, and prescription drugs, this program pays for itself over and over again. You will find that your allergies will start to disappear - if not totally be gone - at the end of 5 days.

Free Report: The Five Basic Secrets To Healing Your Sinuses - Learn how to cure your sinus infection for good in the next 24 hours using a natural home remedy that’s guaranteed to work. The 24 hour sinus breakthrough is a powerful 100% natural treatment for sinus infections, sinusitis & allergies. Save yourself from sinus surgery, endless rounds of antibiotics and expensive doctors and medications. Stop your sinus misery permanently using an all natural, gentle home remedy that clears your sinuses, allows you to breath and gets rid of your sore throat and sinus headache for good.

Fun With GF/LG Food: Gluten Free Low Glycemic Cookbook for Diabetics & Allergy Sufferers - Have fun making yummy, gourmet tasting, gluten-free, low-glycemic meals and delicious desserts the quick and easy way. This is an ebook cookbook by Debbie Johnson, former owner and executive chef of The Golden Chalice Restaurant & Gallery, a 100% gluten-free, sugar-free, low-glycemic, organic, allergy-friendly establishment. This cookbook is gluten-free, low-glycemic, allergy-aware with meat, vegetarian and vegan options throughout. Every recipe in this book contains "healing" food of some type. These recipes have been helpful for people with everything from celiac disease and diabetes to IBS (irritable bowel syndrome).

Gluten Free Low Glycemic Cookbook

 


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