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Back to the special report on
Glutatathione and whey protein in HIV-AIDS

CTN Trial Results

Whey Protein for Wasting

CTN079: Multicentre, Double-blind, Randomized Control Study of Whey Protein Concentrate vs Casein in Patients with AIDS and Wasting Syndrome

Objective: The purpose of the whey protein study was to determine whether a whey protein concentrate (WPC) had an impact on the weight of HIV patients suffering from wasting syndrome.

Study Design: After a one-month screening period, volunteers were randomized to Diet Regimen A (WPC) or Diet Regimen B (casein - another milk product used as a control). Treatment continued for six months. Researchers monitored weight gain to judge the efficacy of the treatment.

Study Population: Consenting, HIV-infected persons with at least 10 % unintentional loss of body weight participated in this study. They had a stable antiretroviral regimen and were free of opportunistic infections and gastrointestinal disease for the last six weeks at least.

This study began at a time when many patients were beginning to receive the benefits of protease inhibitors and wasting syndrome was becoming uncommon. As a result, only 16 of the expected 60 participants were recruited over a significant period of time and the study was stopped.

Results: Analysis of the results was done in case the magnitude of the difference between groups was much larger than anticipated. In fact, there was no significant difference in the weight gain between the two groups of patients.

Conclusions: The introduction of protease inhibitors drastically reduced the number of patients with wasting syndrome and accounted for the failure to meet the recruitment target. The limited number of participants prevents a firm conclusion on the usefulness of HMS90TM for wasting syndrome.

Note: These results were taken from an abstract presented at the CAHR conference 2000.

Return to trials database.



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